Capturing millions of people and selling them as property to support business through slavery will not destroy a nation.
Latter declaring that these people have no legal rights and therefore can not even be citizens of your nation will not destroy a nation.
Forcing native inhabitants to move from their homelands to horrible living conditions – killing thousands in the process – will not destroy a nation.
Sending hundreds of thousands of people into internment camps just because they are the same ethnicity as the country that you are fighting with will not destroy a nation.
Dropping bombs that instantly kill hundreds of thousands of people in an instance will not destroy the nation that dropped the bombs.
Denying equal rights, voting, pay, voice, and other basic aspects to over half of the population of a nation just because they are women will not destroy a nation.
Hundreds of years of atrocities, murders, lies, cover-ups, unethical experiments, hatred, greed, mistreatment of the poor, abuse of children, and many other sins will not destroy a nation.
What is finally going to get God mad enough to destroy America (or let America destroy itself)?
Marriage equality and transgender bathroom access.
Two issues not even directly mentioned in the Bible… unlike all of the things above. But sure, God is going to finally hit that smite button because we let people marry who they want, and go pee where they feel comfortable.